Share on Twitter Share Share on Facebook LinkedIn Pinterest Email A new study sheds light on the significance of a potential genetic risk factor for drug addiction and possibly other neuropsychiatric disorders. Both genetic and environmental factors are known to influence susceptibility to substance use disorders. However, the genetic basis of these disorders is largely unknown.Researchers at Boston University School of Medicine (BUSM) have for the first time identified a gene that is casually associated with the behavioral stimulant response to the drug methamphetamine. The gene, known as heterogeneous nuclear ribonucleoprotein H1 (Hnrnph1) has never been previously implicated in the behavioral effects of psychostimulants such as amphetamines or cocaine.These findings could have implications for understanding the genetic basis of methamphetamine addiction in humans and the development of novel therapeutics for prevention and treatment of substance abuse and possibly other psychiatric disorders. The study appears in the journal PLOS Genetics. Using an experimental model, researchers were able to identify a region of a chromosome that was causally associated with differences in sensitivity to the stimulant properties of methamphetamine. Utilizing genetic approaches such as “fine mapping” and “genome editing,” the researchers narrowed the region of the chromosome and targeted each gene to responsible for affecting the behavioral response to the drug.According to the researchers, Hnrnph1 codes for an RNA binding protein that regulates the processing of hundreds of other genes in the brain. A top priority now is to identify the direct genetic targets of Hnrnph1 within the reward circuitry.“A better understanding of the brain region and cell type-specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction – a disorder for which there is currently no FDA-approved drug,” explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.The researchers believe this discovery may be potentially relevant to other neuropsychiatric disorders involving dopaminergic dysfunction (ADHD, schizophrenia and bipolar disorder) and have implications for neurodegenerative disorders that affect dopamine circuits, including Parkinson’s and Huntington’s disease.
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Lancaster-based First Subsea has signed a multi-million pound contract with DONG Energy for Hornsea Project One offshore wind farm cable protection systems (CPS).The order is for 151 CPS units, and marks the first major UK contract in renewables for First Subsea, which should allow the business to diversify into this market.John Shaw, managing director, said: “This contract agreement is the culmination of years of hard work at First Subsea and a very proud moment for us all. We recognised the growth of the renewables industry, particularly offshore wind, when we applied for the grant to develop our processes a few years ago. We knew it would be hugely beneficial in the long term if we were able to diversify. “Delivering on this contract with a global player like DONG Energy will demonstrate our capabilities to the rest of the offshore wind industry, both in the UK and hopefully wider into Europe too. I can’t stress how much of a great opportunity this is for our business.”Hornsea Project One will be built 120 kilometres off the Yorkshire Coast. It will be the first offshore wind farm with a capacity over 1GW and capable of powering well over one million homes.
There were signs that the industry was slowing down prior to the referendum vote in June and the resultant economic uncertainty immediately after the referendum was bound to cause waves. According to the press, there has now been the fastest fall in activity since the dark days of 2009. Is it possible, however, at this very early stage, to anticipate the emergence of any new trends in the industry?Earlier this year, Building asked if the role of the construction manager was about to disappear or whether it was due to bounce back (“Last chance to see?”, 24 June 2016, page 22), and, post-referendum, it does seem that construction management is having a resurgence of popularity with developers. Before the referendum, they were struggling on the domestic project front to make projects stack cost and risk allocation with main contracting procurement, as construction costs spiralled and the balance of power swung towards the contractor. Then came the referendum result, with developers tightening their belts and trying to increase control over efficiency, costs and the fall in construction activity.So why might construction management become flavour of the month?Some developers have operated construction management successfully for years and found that it has given greater flexibility and costs savingsConstruction management sees the employer entering into a direct trade contract (possibly via a framework) with all trade contractors for the packages necessary to deliver the project, be that demolition, piling, substructure, superstructure, cladding, lifts, finishes, and so on, and the employer appointing its professional team under consultant services agreements in the usual way.The theory is that by cutting out the main contractor and procuring trade contractors directly, the employer has access to the same supply chain as a main contractor under a design and build or traditional arrangement, but can reduce the amount of overheads and profit it has to pay. Some developers have operated construction management successfully for years and found that it has given greater flexibility and costs savings. Unlike design and build main contracting, where an employer’s agent is engaged to manage the main contract and carry out administrative functions, under the construction management route the employer acts as construction manager itself or appoints an external construction manager to manage the procurement.Apart from potential costs savings, what are the advantages of construction management? These can include: a shorter programme achieved by overlapping design and construction following early appointment of the consultant team and specialist trade contractors, proactive management of the design and construction process to minimise disruption, more flexibility to implement cost effective solutions to problems, and that the project is less likely to be derailed by insolvency of a trade contractor when compared with that of a main contractor.What is there not to like? Construction management is not for everyone. There is no cost certainty until all trade packages are letSo what is there not to like? Construction management is not for everyone. There is no cost certainty until all trade packages are let and no single point responsibility – one of the main upsides of design and build. There is an increased administrative role for the employer, who is fully exposed to the risks associated with the performance of the construction manager and the rest of the team. Finally, certain funders may be nervous about construction management, although this could be less of an issue if trade contracts can place single point responsibility on the relevant contractor for design/performance as well as for workmanship.The most important thing to remember, if considering construction management, is the significance of the construction manager. The construction manager will need to have a particular skill set in order to operate this form of procurement efficiently and for an employer to benefit from the advantages that may be available. The role of the construction manager goes beyond the scope of that of a main contractor or of an employer’s agent. The client needs to have the resources and expertise to be able to manage the procurement process effectively. Berkeley Group is a good example of a successful and informed client who has used construction management for years with great success. If an employer/client does not have that resource and the expertise in-house, the importance of appointing a construction manager who is both experienced in operating this type of procurement and has the specialist knowledge to ensure successful project delivery is crucial. Big build-to-rent outfit Essential Living has opted for this approach in its recently announced move away from main contracting to construction management.Are the winds of change really blowing through the more traditional methods of main contracting procurement of developers? If so, it may not be a bad thing. But, as with all departures from any well-established practice, an element of not only sophistication but also caution is vital.Stephanie Canham is head of construction at law firm Trowers & Hamlins
Local authorities have been told to stop running to the High Court every time a child vaccination dispute arises as the court’s time could be better spent dealing with urgent family matters.The Court of Appeal said the case in Re H (A Child) (Parental Responsibility: Vaccination), handed down this week, provided an opportunity to ensure further delay and public expense in similar cases could be avoided.The appeal court was asked to identify the proper procedural route that local authorities should adopt when vaccination disputes arise with parents of a child in care.Giving the lead judgment, Lady Justice King said it was ‘axiomatic’ that local authorities must involve parents in decision-making and take their views into account. The Children Act 1989, she said, ‘is not an invitation to local authorities to ride roughshod over the wishes of parents whose children are in care’. However, a parent’s application to seek an injunction with a view to preventing a child being vaccinated ‘is unlikely to succeed unless there is put before the court in support of that application cogent, objective medical and/or welfare evidence demonstrating a genuine contra-indication to the administration of one or all of the routine vaccinations’.The administration of standard or routine vaccinations is not a ‘serious’ or ‘grave’ matter, Lady Justice King said. ‘Except where there are significant features which suggest that, unusually, it may not be in the best interests of a child to be vaccinated, it is neither necessary nor appropriate for a local authority to refer the matter to the High Court in every case where a parent opposes the proposed vaccination of their child. To do so involves the expenditure of scarce time and resources by the local authority, the unnecessary instruction of expert medical evidence and the use of High Court time which could be better spent dealing with one of the urgent and serious matters which are always awaiting determination in the Family Division.’Lady Justice King ruled that the declaration that the local authority has lawful authority to make arrangements for vaccinating the child stands, notwithstanding the parents’ objections. Lord Justice McCombe and Lord Justice Peter Jackson agreed.
JULY 13 is the deadline for anyone interested in financing the development and construction of the proposed Amsterdam – Antwerpen high speed line to respond to a consultation document issued by the Dutch government at the beginning of June. The Ministry of Transport’s high-speed line office has appointed Cameron McKenna and Greenwich NatWest to advise on the scope for private sector participation, which could cover up to 10% of the total cost.Following the signing of an accord with the Belgian government which commits the Dutch to completing the route by 2005, the ministry is anxious to push ahead with the project. The final planning approvals are expected to be completed this summer, with contracts for the major civil works to be awarded by the end of the year.The consultation document sets out details of the project and the government’s aim of involving private-sector promoters in some form of partnership. The responses are expected to stimulate a wider debate about the exact formula for private involvement, in time for the project office to invite formal tenders later this year. Issues flagged up for consideration include the allocation of capacity between international and domestic services, the relationship between the private promoters and the train operators, and the ownership of rolling stock, stations and other sub-elements.Cost of the 300 km/h line is currently put at 17·5bn guilders, of which the majority will go on civil engineering work. Mechanical and electrical equipment will be expected to conform to the specifications of the European Rail Traffic Management System. o
Congo defeats deadly Ebola once again An electoral agent arranges ballots at a polling station in Kinshasa, on December 31, 2018 the morning after the presidential elections. – The Democratic Republic of Congo on December 31, 2018 began counting ballots from a presidential election marked by delays and fears of violence and vote-rigging, straining hopes for its first-ever peaceful transfer of power. (Photo by Marco LONGARI / AFP) (Photo credit should read MARCO LONGARI/AFP/Getty Images) An electoral agent arranges ballots at a polling station in Kinshasa, on December 31, 2018 the morning after the presidential elections. – The Democratic Republic of Congo on December 31, 2018 began counting ballots from a presidential election marked by delays and fears of violence and vote-rigging, straining hopes for its first-ever peaceful transfer of power. (Photo by Marco LONGARI / AFP) (Photo credit should read MARCO LONGARI/AFP/Getty Images)Long-awaited legislative elections are underway in three provincial centers in Congo after authorities postponed them because of Ebola and violence.In the town of Beni on Sunday, voters were washing their hands before entering polling centers as a protection against Ebola, which is transmitted by the bodily fluids of sick people.Voters in Beni, Butembo and Yumbi were not allowed to vote in January when Congo chose a new president. Officials said the Ebola virus posed too great a threat at the time in the eastern cities of Beni and Butembo.Elections were delayed in Yumbi because of inter-communal violence.Voting turnout was expected to be low. Albert Somo, a teacher in Beni, said people were disappointed and discouraged because they were not permitted to participate in the presidential vote.Related Congo confirms Ebola case at Ugandan border Ebola: Guinea and Congo Presidents Address UN
2255 Views no discussions Share Share (L-r) Tasia Floissac, Abigail Shillingford, Britney Pharaoh, Nawana Shillingford, Mernel Christmas, Judy Toussaint.Six young ladies who will vie for the Miss Dominica 2016 title have been officially announced and sashed.The contestants are Judy Toussaint, 20, of San Sauveur, Mernel Christmas, 19, of Campbell, Nawana Shillingford, 25, of Loubiere, Britney Pharaoh, 22, of Grand Bay, Abigail Shillingford, 19, of Goodwill and Tasia Floissac, 22, of Castle Comfort.Chairman of the Dominica Festivals Commission, Colin Piper commended the young ladies for participating in the competition scheduled for 5 February 2016.“We are here to support these young ladies who are giving up their time, giving up their talents to contest in the National Queen Show Pageant. This is a very courageous and selfless act. One that we know exposes these you ladies to criticism we live in”.“We believe that you all are very intelligent and talented and therefore we encourage and support you as you use this platform in your quest to perform to the best of your ability,” Mr Piper continued.Mr Piper called on corporate citizens to sponsor the contestants and support Mas Dominique 2016.“We look forward for partnerships with the corporations in Dominica to come and sponsor, not only the six intelligent young ladies, but also to partner with the Discover Dominica Authority in putting on carnival”.Meanwhile, Chairperson of the Queen Show Committee, Romulda Hyacinth informed that the contestants are in full training for the pageant. “They are aware that the decision to enter the pageant means undergoing the task of becoming a role model of young ladies of this beautiful island, it is a decision that is by no means easy and entails many sacrifices.”Mrs Hyacinth added that the Dominica pageant is not just a beauty pageant but an opportunity for young ladies to further their education and become leaders in their community. “The experience and exposure gained from this journey is invaluable and will impact and will impact these young ladies positively for a life time,” she stated.– / 32 Tweet Share EntertainmentLocalNews 2016 Carnival queen contestants introduced by: Dominica Vibes News – November 26, 2015 Sharing is caring!
Tweet 1897 Views no discussions The St. Thomas [Parish] woman who was seen in a video on social media beating her 12 year old daughter with what appeared to be a machete, will not be able to having her teenage daughters back under her roof until they are adults. Doreen Dyer, 44, was back in court in St. Thomas [Parish, Jamaica], on Thursday trying to regain custody of her daughters.Senior Parish Judge Fiona Feare-Gregory ruled that the twin girls, who are now 13 years old, will remain in the custody of their aunt 2023 when they will be 18 years old. The judge has indicated, however, that Miss Dyer will be able to see the children on weekends in the presence of their legal guardian. Miss Dyer is not happy with the decision of the judge but has accepted. “Me cyaan feel good, me feel upset; but me cyaan do nothing,” she expressed. Earlier this month, Miss Dyer appeared in Court where she was sentenced to three years’ probation and ordered to get parental counselling as well as attend anger management classes. Share Sharing is caring! Share Share NewsRegional Woman who beat daughter with machete not allowed to live with children until they are 18 by: Caribbean News Service – February 23, 2018
FacebookTwitterEmailPrintFriendly分享WINTER WEATHER ADVISORY IN EFFECT FROM 3 a.m. to 4 p.m., Sunday, November 19, for the Western Kenai Peninsula. Expect snow and blowing snow with high winds. Plan on slippery road conditions. In addition, areas of poor visibility is expected. Total snow accumulations of 4 to 7 inches are expected. Winds gusting to 20 mph will cause areas of blowing and drifting snow. Including the cities of Kenai, Soldotna, Homer, and Cooper Landing. For more information https://inws.ncep.noaa.gov/a/a.php?i=17033255